• br Discussion and conclusion Ubiquitination

  2019-07-19

  

  Discussion and conclusion Ubiquitination and deubiquitination have emerged as important mechanisms involved in p53 management. This review revealed that various DUBs can regulate p53 or p53-Mdm2-MdmX networks. Herein, we reviewed the current progress made toward elucidating the complexities in th

• Mono and bi ubiquitination of two lysines

  2019-07-19

  

  Mono- and bi-ubiquitination of two lysines, namely K70 and K76, in a small fraction of p33 replication co-factor has been demonstrated in yeast (Barajas and Nagy, 2010, Li et al., 2008). Because mutations of these lysines reduced TBSV repRNA replication in yeast and affected the ability of p33 to in

• The human serotonin hydroxytryptamine HT receptor family con

  2019-07-19

  

  The human serotonin (5-hydroxytryptamine; 5-HT) receptor family consists of 14 receptor subtypes to date, which are primarily G protein-coupled receptors (GPCRs) with 5-HT3 being the sole ligand-gated ion channel (Alexander et al., 2017). These receptors are widely distributed in the central and per

• br Conclusions In conclusion we identified and overexpressed

  2019-07-19

  

  Conclusions In conclusion, we identified and overexpressed DGAT2 in fast growing, oleaginous N. oceanica for the first time. The engineered N. oceanica overexpressing DGAT2 resulted in enhanced neutral lipid accumulation and altered fatty bcl-2 inhibitor composition. Altogether, our findings dem

• br Conflict of interest statement br Acknowledgement The stu

  2019-07-19

  

  Conflict of interest statement Acknowledgement The study was financially supported by the Ministry of Education, Youth and Sports of the Czech Republic – projects “CENAKVA” (No. CZ.1.05/2.1.00/01.0024) and “CENAKVA II” (No. LO1205 under the NPU I program), by the Grant Agency of the University

• The purposes of this study are to investigate

  2019-07-18

  

  The purposes of this study are to investigate the molecular function of DDR2, especially in cellular proliferation in prechondrocytes, and to examine the relationship between the proliferation and differentiation of prechondrocytes through both in vitro and in vivo analysis. Materials and methods

• In order to assess quantitatively the

  2019-07-18

  

  In order to assess quantitatively the contribution of the ung, dug and dut EDC.HCl to uracil-DNA accumulation in E. coli, we have developed a novel method for measuring uracil residues in DNA that is based on the approach of Kow and co-workers [33] for measuring AP-sites in DNA. The method, which we

• Keratin K has been identified as the

  2019-07-18

  

  Keratin 8 (K8) has been identified as the first intermediate filament expressed during development in amphibians and mammals. In zebrafish, a type II cytokeratin 8 (zf-K8) cDNA has been cloned. zf-K8 gene was maternally inherited and expressed in all surface cells throughout the embryonic stages old

• Introduction Tumor necrosis factor TNF is a

  2019-07-18

  

  Introduction Tumor necrosis factor (TNF) is a pro-inflammatory mediator with the capacity to induce apoptosis (Benderska et al., 2012). Recent reports have shown that TNF might trigger cell death, at least in part, by directly affecting the reorganization of the BIIB021 cytoskeleton (Campos et al.

• In summary our findings show that LPS can activate CysLT

  2019-07-18

  

  In summary, our findings show that LPS can activate CysLT2R on microglial PPM-18 chemical to induce microglial inflammation and microglia-dependent neuronal death. Furthermore, pharmacological inhibition or knocking down of CysLT2R expression protects neurons against neurotoxicity via suppression o

• The absorption rate of polyphenols into the body is usually

  2019-07-18

  

  The GSK1904529A rate of polyphenols into the body is usually low. For example, the absorption rate of epigallocatechin gallate (EGCG), an active component in GP, is approximately 1% (Chen et al., 1997). To increase absorption of GP in the body, people have been increasing their intake of functional

• Water solubility experimental data of water hydrocarbon mixt

  2019-07-18

  

  Water solubility experimental data of 24 water + hydrocarbon mixtures are used to find a general correlation for CPA model parameters. Finally, the model is benchmarked against three complex water solubility data set (Athabasca bitumen + water mixtures) from the literature [25], [26]. The model reli

• br Methods and materials br

  2019-07-18

  

  Methods and materials Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic Carmofur to prostaglandin, prostacyclins and thromboxanes., , , Two distinct isoforms of COX were initially discovered: COX-1 is a constitutive, housekeeping enzyme that is expressed in man

• Cot MAP K is the sole MAP K

  2019-07-18

  

  Cot (MAP3K8) is the sole MAP3K that activates the MEK1/2-Erk1/2 following the activation of the TLR/IL-1 receptor superfamily as well as some receptors of the TNF receptor family [8], [9], [10] and mediates the production of chemokines and cytokines in different cell systems [reviewed in [11]]. Thus

• br Results and discussion br Conclusion In this investigatio

  2019-07-18

  

  Results and discussion Conclusion In this investigation, pharmacophore models of CK1 inhibitors were developed using a pharmacophore modeling protocol proposed by us. The optimal pharmacophore hypothesis, Hypo2, was adopted to retrieve potential CK1 inhibitors from the commercial chemical data

16137 records 1029/1076 page Previous Next First page 上5页 10261027102810291030 下5页 Last page