• br Aromatase inhibitors The aromatase enzyme P

  2024-03-05

  

  Aromatase inhibitors The aromatase enzyme, P450arom, belongs to the super-family of P450 proteins which includes more than 480 members divided in 74 different families. P450arom is a unique member of family 19 [39], and is located in the endoplasmic reticulum of mammalian 94 6 that express the C

• The fluorescence in a fluorescent antibiotic can be derived

  2024-03-05

  

  The fluorescence in a fluorescent antibiotic can be derived either from functional groups with intrinsic fluorescence in an existing antibiotic, or via synthetic conjugation of a fluorophore to an antibiotic core to enable visualisation. Attachment of fluorophore to an antibiotic should ideally not

• br Concluding Remarks and Future

  2024-03-05

  

  Concluding Remarks and Future Perspectives Fluorescent Pazopanib have helped researchers to elucidate antibiotic MOA and off-target interactions, to screen for new antibiotics, to detect antibiotics in the environment, to track antibiotic uptake throughout cells and organisms, and to detect bact

• The use of one or more of psychotropic medications

  2024-03-04

  

  The use of one or more of psychotropic medications and hypnotics was associated with a higher risk of falls in the current study. Previous studies have also shown that these medications increase the risk of falls in the geriatric population.25, 26, 27, 28, 29, 30, 31 Clinicians should weigh the risk

• Defining the multiple roles of

  2024-03-04

  

  Defining the multiple roles of autophagy in stroke has been a rapidly evolving and exciting venue for translational research, with innovative products being applied from bench to bedside. Spanning pharmacological pathway manipulation and functional experimental validation, altered autophagy activati

• br Materials and methods br Results br Discussion Japanese e

  2024-03-04

  

  Materials and methods Results Discussion Japanese encephalitis caused by JEV is characterized by n oxide neuron death. However, the underlying mechanism is not fully understood. We and other researchers have demonstrated that JEV induces apoptosis by ER stress-mediated IRE1/JNK and ROS-med

• In large biopsies series from ALK NSCLC treated

  2024-03-02

  

  In large biopsies series from ALK+ NSCLC treated patients, the number of detected mutations increased after second generation ALKi (Gainor et al., 2016) and in one study were present in 56% of the entire cohort (Shaw et al., 2013b). For example, the rate of G1202R mutations increases from 2% in post

• Introduction A defining feature of cancer cells is disruptio

  2024-03-02

  

  Introduction A defining feature of cancer cells is disruption of the normal controls of the cell cycle; a tumor suppressor or inhibitor may act by restricting progression of the cell cycle. P27 (also known as cyclin-dependent kinase inhibitor 1B, P27, or Kip1) is a putative cell-cycle inhibitor pro

• While the direct effects of ARI lead

  2024-03-02

  

  While the direct effects of 5-ARI lead to a dramatic LY2874455 in serum DHT levels, other laboratory values are also affected by 5-ARI use. Serum testosterone elevations are known to occur with both finasteride and dutasteride use, but values will typically remain within the normal laboratory range

• Our sample is representative of mRCC treated with sunitinib

  2024-03-02

  

  Our sample is representative of mRCC treated with sunitinib. However, the results from CCC setting have limited inference due to small exploratory sample (n = 51). Additionally, the significance of survival differences in CCC according to AXL staining is tangential. Unfortunately, we were unable to

• This project was funded by the University of the

  2024-03-02

  

  This project was funded by the University of the Philippines Diliman through the Natural Sciences Research Institute with grant No. CHE-09-2-02. Introduction There is compelling evidence for an anti-inflammatory effect of 12- and 15-lipoxygenases through the generation of lipid mediators involve

• The first objective of the present study was

  2024-03-01

  

  The first objective of the present study was to investigate the impact of ageing on arginase activity in tissues which exhibit age-related impairments in their function. The second objective was to determine whether l-arginine supplementation modulated the effect of ageing on arginase activity. The

• br G protein activation through croaker ZIP

  2024-03-01

  

  G protein activation through croaker ZIP9 An essential criterion for designating a steroid binding protein as a membrane steroid receptor is to demonstrate that it can transduce steroid signals in order to elicit a cellular response. Treatment with 100nMT caused G protein activation in croaker ZI

• As patients with type diabetes are known to be hyperinsuline

  2024-03-01

  

  As patients with type 2 diabetes are known to be hyperinsulinemic per se, this relationship between insulin/IGF1 receptor and AR may point towards a causal role of insulin in AR upregulation. Indeed, this is supported by several previous observations. Beyond the already mentioned AR activation by in

• Rizatriptan Benzoate br Summary and future br Introduction A

  2024-03-01

  

  Summary and future Introduction Androgen activity is critical for a wide range of developmental and physiological responses and is especially important in male sexual differentiation and maturation. The biological activity of androgens occurs through binding to the androgen receptor (AR) and t

16138 records 192/1076 page Previous Next First page 上5页 191192193194195 下5页 Last page